Microwave assisted preparation of C1-C11 oxygen-bridged pregnanes.

نویسندگان

  • Lautaro D Alvarez
  • Juan M Sonego
  • Adriana S Veleiro
  • Gerardo Burton
چکیده

1,11-Epoxysteroids may be obtained by an intramolecular remote functionalization using Suarez reagent (diacetoxyiodobenzene/I(2)) and irradiation with visible light. We have found that photolysis with visible light may be advantageously replaced by microwave irradiation to prepare 1,11-oxygen bridges resulting in higher yields and shorter reaction times especially in the case of sensitive substrates. Both methodologies were compared on a set of representative 11-α-hydroxypregnanes (3, 8, 10 and 11).

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عنوان ژورنال:
  • Steroids

دوره 76 13  شماره 

صفحات  -

تاریخ انتشار 2011